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Master Thesis at the University of Kirkuk Discusses the chemical profile of carbonic anhydrasec in red blood cells for patients with blood diseases

04 March 2019
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The Master Thesis at the Faculty of Science at the University of Kirkuk discussed a scientific study on the chemical characterization of the carbonic anhydrasec in the red blood cells of people with blood diseases by Salwa Saleh Hussein Sultan.

The study included the study of the extraction of CA enzyme from the human red blood cells in patients with the major beta thalassemia and healthy people, the protein measurement and the specific efficacy of the enzyme extracted from red blood cells in all studied groups, the study of purification of the enzyme using several different steps of patients, Kinetics and thermodynamic variables, as well as the effect of inhibition with dioxy-cyclone DC on the effectiveness of the enzyme.The study concluded that the migration of CA packets in the patients was found to be less frequent or denser in the patients than in the healthy ones, as was their density in the selected samples. In the study of the DMD, the result was moderate to good and the inhibition value was high At a concentration of 500Mm, and that the IC50 value of enzyme activity with the inhibitor was higher than 50%.The researchers recommended further studies to indicate the importance of the efficacy of CA in patients with major beta thalassemia. The effectiveness of CA enzyme in post-treatment patients and the study of reverse DNA treatment by gene therapy should be evaluated.sc1


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