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Master Thesis at the University of Kirkuk discusses a scientific study on the effect of alopurinol derivatives on the growth and metabolism of leishmaniasis

28 October 2018
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A Master Thesis at the Faculty of Science at the University of Kirkuk discussed a study on the effect of alopurinol derivatives on the growth and metabolism of Iraqi Leishmania parasite student Marwa Abdel-Karim Bakr.
The thesis included the test of the efficacy of alopurinol on the visceral leishmaniasis and the feasibility of its mechanism of action by studying its effect on the content of this parasite of proteins and nucleic acids, as well as its effect on some of the basic enzymes in the processes of nucleo tides production.
The study concluded the effectiveness of the effect of alopurinol and its derivatives on the growth of lemishmanium bromocycotate and low concentrations, which will be integrated into nucleic acids and impede the building of proteins, which will stop the growth and reproduction of parasites.
The study recommended the study of the effect of leopiorinol and its derivatives on the growth of the amyticotite stage of leishmaniasis parasites in laboratory animals, study the morphological changes that may be obtained for the organic composition of these parasites using electronic microscopy and study the effect of alopurinol and its derivatives on the effect of enzymes that stimulate the pathway of biosynthesis.

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